Yes, Nutcache can easily handle both specific and automatic transaction numbering.

Specific numbering
Nutcache will increment your transaction numbers based on the next transaction number you enter. For instance, if you create an invoice and enter 00043222 as the transaction number, next time you create an invoice, Nutcache will display 00043223 as the default transaction number.

Automatic numbering
Automatic numbering is an option you can set through the organization settings.